People knowledgeable about biology...

[gopunk]

http://biocrs.biomed.brown.edu/Darwin/DI/clot/Clotting.html

about 75% down the page...

could someone explain to me why the 2-level cascading system of converting fibrinogen is more efficient than the one level one with both A and B?

it says:

The new 2-step system allows each TF to activate a protease B, each of which in turn can activate scores or hundreds of A's.

but i mean, previously, each TF could activate either a A or a B, which in turn could also activate scores or hundreds of A's or B's, right?

is it just because A and B would be allowed to get more specialized at what they're doing?

i have to run to class, but i eagerly await the answer... thanks 🙂

 

[gopunk]

bump

 

You might get a response if your link worked.

 

[gopunk]

Originally posted by: SammySon
You might get a response if your link worked.

it does work....

 

[petery83]

i'm not sure if i'm understanding correctly (i apologize if i'm not), but with multiple levels, it's going to increase faster since some of the first products from the TF (i.e. "B") could go on to make even more of the final product ("A") as TF is making more "B" (thus increasing exponentially) while with a 1-level system, the initial product ("A") doesn't generate new product, so it's more of a constant increase