it'll work just fine - in fact, the memory will actually be running faster than the bus. 1333MHz FSB is really a 333MHz quad-pumped. when running in 1:1, each channel gets half the bandwidth, so each stick will run at 667MHz. You would have to run a 3:2 divider or just overclock your FSB (and hence your CPU) in order to get the memory running at 1000MHz. I recommend the latter because C2Ds are great overclockers.