Overclocking problem. Please help.

[Brannigan]

When ever I have my pc overclocked while playing F.E.A.R. the dvd-rw that the game disk is in makes a constant and frantic seeking noise. If I return the computer to stock speeds in the bios this does not happen. I have confirmed the noise is coming from said drive by pulling out the power cable and hearing the noise stop instantly. I have also confirmed a pci\pcie lock using clockgen. The drive and the cable are both new. Any ideas?