There is no mobo that can do 6x500 and no one will know if it is better than 10x300.
Plus, your memory will not be able to work @ 500 mhz.(DDR1000)
The best HTT was acheived by anandtech on ULI refrence board at lower multi and HTT400.
But most boards are not capable of more than 340mhz. but then you have to have a memory to work at that speed too, to give you highest bandwidth and highest cpu speed at highest multi.
So the best bet is to use the stock multi ( highest multi).
You can look at it this way. Venice 3000 is 9x multi, but a 3200 has 10x.
so running a 3200 @ 9x is like having a 3000 cpu.
why would anyone want to downgrade their cpu? another word, those w/ venice 3000, would be extremely happy if it was 10x instead of 9x.
You get the picture?