780i is fine for OCing Q6600s, at least the EVGA FTW version I had was. It took some work, but I had it at 3.6, just the temps were too high with the cooling I had. My regular OC (and now my friend's) is about 3.2 GHz on the board with a Q6600 G0. Keep in mind with quads, MCP overvolting may/probably will be required.
Here's an update. I think I am stably at 3 GHz and 1.25 V with 889 MHz memory, and I will keep it like this for 24/7. Intel speedstep is enabled, and temperatures are fine. That 2% tweak made the difference. The board is an MSI P6N-SLI, using the GeminII cooler.
I could explore whether I could get a few hundred more megahertz, but I probably won't anytime soon.
Edit2: You basically get very little or any improvement running faster than 1:1 memory ratio. Think 0-3%. Easily made up for with a better overclock.