Sure you can. In the BIOS you'll have an option in Advanced Chipset Features. You'll see and option for HostClk + 33 (or 133) set it at that. Or if you download the 1.8 or 1.9 BIOS form MSI's site you'll see DRAM BY SPD, say NO for this then go to DRAM CLOCK and set it for 133. Also change the CAS Latency to 3 at first, this will put less strain on your memory. But if it can handle 133 at CAS 2 (mine can) then go ahead set it for that.