Just off the top of my head....
Alt + F File menu options in current program.
Alt + E Edit options in current program
F1 Universal Help in 90% of Windows programs.
Ctrl + X Cut selected item.
Shift + Del Cut selected item.
Ctrl + C Copy selected item.
Ctrl + Ins Copy selected item
Ctrl + V Paste
Shift + Ins Paste
Home Goes to beginning of current line.
Ctrl + Home Goes to beginning of document.
End Goes to end of current line.
Ctrl + End Goes to end of document.
Shift + Home Highlights from current position to beginning of line.
Shift + End Highlights from current position to end of line.
Ctrl + Left arrow Moves one word to the left at a time.
Ctrl + Right arrow Moves one word to the right at a time.
Ctrl + Backspace Delete word to the left of cursor.
Ctrl + Del Delete word to the right of cursor.
Alt + Tab Switch between open applications.
Alt + Shift + Tab Switch backwards between open applications.
Ctrl + Esc Bring Up start button.
Alt + Esc Switch Between open applications on taskbar.
F2 Renames selected Icon
F3 Starts find from desktop
F4 Opens the drive selection when browsing.
F5 Refresh Contents
Alt + F4 Closes Current open program.
Ctrl + F4 Closes Window in Program
Alt + Enter Opens properties window of Selected icon or program.
Shift + F10 Simulates right click on selected item.
Shift + Del Delete programs/files without throwing into the recycle bin.
Holding Shift Boot safe mode or by pass system files.
Holding Shift When putting in an audio cd will prevent CD Player from playing.