I just recently restarted and am playing through, although I've had the game for a couple of years. I'm running the CallSteed3.0a mod for summoning my horse, MD_Saddle_Bags for saddle bags (these two together make adventuring much more enjoyable for my spellsword, as I can haul more stuff around). I'm also using ShortGrass V3 for better performance, and tag_NaturalWildlife just because the stock wildlife scripts are often stupid. I also have a small mod I made to slightly increase walk speed for myself and mount.
I played with Oscuros the last time around, and I'm still attracted to what it tries to do. The stock levelling can seem quite stupid. All of a sudden at level 22 every bandit my character encounters is equipped with glass, ebony, and daedric armor and weapons, and I'm awash in gold from selling it all. The fights stay very tough, but the downside is you never really conquer your way to the point that you can walk through some place without fear. What used to be a rat in the woods at level 5 is now a Minotaur Lord who stuns for 2 seconds on every slug.
I might give Oscuro's another try if I do a new character.