On my Crosshair VI Hero I had minor contact with the tubing against my RAM. That said, I didn't realize that you can mount it on there almost any way you want. You can re-orient the bracket on the block so that the tubes extend under or over the water block (or to the left side if you want, it's up to you). It's simply worth noting that the NZXT logo is fixed, and so the logo will be rotated as well. On my wife's build, we rotated the block a little so that the water tubing exits at about 45 degrees. from the block. It tilts the NZXT logo accordingly, but she doesn't mind at all, and removes any possibility of cramping the DIMMs.