Safe as Church on Sunday. NVMe protocols do not call up a new partitioning scheme. Just establish the drives/volumes as you would for a hdd.
Just as an aside though, I am not a fan of establishing multiple drives on a single disk. That architecture was very useful to cave men, when disks were small and space was scarce ( although I remember those days fondly myself). The unavoidable risk though was losing all your data if the disk went down.
Unless you are a pauper and/or live in the in the land of retail larceny you perhaps can afford a second disk to take application ( usually games, eh ? ) installs. Or perhaps, adapt a current drive ? There is a margin of security available here if you make the second disk bootable and you will also have the separate disk to use for a backup OS image or clone, both of which results can be very handy when the main disk goes walkabout.