Personally, I run every game I possibly can at 1600x1200 without FSAA.
I never could understand why I should go to a lower resolution & "blur" it to make it look pretty, when I can play at a much higher "sharper" resolution.
EXAMPLE: I can run Nascar 4 at 1600x1200 non FSAA with 26cars drawn in front & 4 behind, or I could do 800x600 with FSAA with 42 in front & 42 behind, but once you play a game in 1600x1200, theres no going back!
Of course this is all subject to personal opinion & I couldnt help but add my .02 cents worth.