On certain CF mobos, yes. *BUT* you need to use hacked drivers that are unsupported. Last I heard there are two versions and they are older driver files so there could be (and I do believe there have been many) incompatibility issues with various modern games. Also the cards wont run in full normal SLI mode. I think the PCIe throughput speed is cut in half if I remember correctly. Instead of 8x8 you get 4x4 or something like that. You can find the drivers and more details at XtremeSystems.org.