can you be a little more vague?
what mobo are you planning to use, what WC stuff do you have already?
on the NF4, you would WC the chipset for silent computing it does not do anything for O/C
for DFI NF4 a little AS5 on the stock cooler or switching to an evercool or vantec cooler is usually all that is needed along with good case airflow if you have a really big video card sitting over the chipset