Normally SMB rides on NetBIOS, but from win2k on, SMB can run directly on TCP/IP -- that's why you can disable netbios on win2k+ and have your network still work. Additionally, CIFS (successor to SMB) is rumored to completely replace SMB/netbios in longhorn (not sure on this).
A LOT of domain admins out there turn of NetBIOS by default because it sucks ... SMB over TCP/IP is a lot better and uses only port 445.
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