I use both NS 6.2 and IE 5.5. I think fonts resolve nicer in NS. I also like the fact that my old NS 4.7x tricks work.
1. All cookies are in one file,
COOKIES.TXT. I make that a zero byte, Read Only file, and set it to accept all cookies. Every site "thinks" it has written its cookie, but it doesn't happen.
2. I keep a copy of a defined startup file, PREFS.JS to a reference directory, and my AUTOEXEC.BAT copys that back to NS on boot up. That way, NS always starts where I want it to.
3. I nuke my cache on bootup.
It's all much easier in NS than in IE.