My biggest concern about negative case pressure is that it does tend to stall air flow through the power supply, possibly resulting in:
- PS runs warmer than designed temp at load.
- PS runs fans at high speed to compensate, increasing case noise.
Positive case pressure is only inefficient - but it can't hurt your PS. For example, 50CFM front intake fan combined with 35CFM rear vent fan will create positive case pressure and:
- Total through-case air flow will be restricted to only a little more than 35CFM.
- Case noise is increased by the 50CFM fan noise.
- Total case air flow would be greater with only the 50CFM front intake fan, since slower-speed fans in series air flow are flow-restrictors.
I've tried negative case pressure in my case (Single Panaflo M1A 120mm rear exhaust with OCZ 520A PS) with no apparent power supply problems, but not all power supplies perform equally and potential long-term effects bother me. I use balanced Panaflo m1A 120mm fans at 7V for flow of about 50CFM with barely audible fan noise.
Hope this helps!