Modern graphics-cards are made to fit in the PCI-E bus. Your motherboard needs to have a PCI-E slot. Almost all motherboards made in the last 8 years or so have one. It doesn't matter if it's a Intel or AMD cpu and motherboard. Both nVidia and AMD videocards will work with both Intel and AMD cpus.
Your only concern might be if you put a very fast videocard in a PC with a very slow CPU. In that case, the slow CPU can hold down the performance of the videocard. So that the videocard will not be able to deliver the high performance that you expected. But it will still work.
Sometimes the GPU card is so big, it physically cannot fit into your computer case, or it will bump against the hard drives or something. So that's also a consideration, how physically cramped your computer is.
And you need to make sure your power supply has enough juice for the graphics card. Some cards only draw power via the motherboard and will work with very low wattage PSU's, while others need one or two 6-pin or 8-pin power cables for extra power.
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