http://gaim.sourceforge.net/win32/index.php
Why do I get a "No disk in drive" (or similar) message? - There is a bug in one of the components of the GTK+ runtime (gettext). As a result, this component attempts to locate a configuration file on the I: drive. If you have an I: drive and it is a removable media drive such as a ZIP drive, CD/DVD-ROM drive, or flash card reader, you will see the an error message stating that there is no disk in the drive or asking you to insert a disk into the drive. If you can change your drive letters so that you have no I: (possible on Windows 2000 or XP), unplug the device if it is a USB device, or insert a disk or card into the drive before starting Gaim, this should silence the message. We hope to have a fixed GTK+ runtime soon. This error message can safely be ignored without any ill effects.