I wonder if the OP is still participating in this thread, but here goes:
I drive 46 miles each way: .25 miles north, ~45 miles east, .25 miles north to work, and the opposite to home. OH St Rt 511 to US224 to I-76/US224/US277 to the Akron Airdock exit, for those who are interested in the details. Avg speed (summer) is 60 mph, including the few stops along the way.
I have been making this commute since 2008, and for the 3 years prior roughly the same commute. Why I choose to continue this awful waste of time is another story, but I would like to offer my experience regarding vehicle choice for this application.
I have a 2007 VW Passat 2.0T / 6M bought new in March 2007 with fairly limited extras: moonroof, heated seats, 6 CD / mp3 / sat radio, etc. in that year's "2.0T", or package 2 option. Once a week I feed it 93 octane gas. Every 5K miles I rotate the tires (learned this the hard way: tires get noisy early if not rotated often - 10K interval is too long for this car). Every 10K I change the oil, about $50 diy.
While there has been 2 major issues with the car, both have been handled to my complete satisfaction by VW. The first was video corruption on the multifunction display LCD under exceptional heat (circumstances were extraordinary); VW replaced the entire cluster at no charge. The second is the well-known BPY engine cam follower failure. This went at ~105K miles (complete failure); VW replaced the cam follower, intake camshaft, and high pressure fuel pump as these are directly connected by the cam follower, again, to my complete satisfaction (free).
Ganley Westside VW in N. Olmsted OH has always been good to me for service, e.g. loaner cars, even for weeks while the HPFP was on back order, no shenanigans with bogus diagnosis, although at 90K miles I decided to man up and start doing my own service (unless free & completely beyond my current ability, e.g. cam follower, intake camshaft, HPFP). Timing belt job at 100K took a *long* time, but I saved a mint. I changed my brakes (rotors & pads all around) at ~125K. I wonder if I will have to change them again.
The car is engaging enough to keep me interested in driving, very stable at high speed, has a phenomenal turn radius, good seats, decent audio system, and now has just shy of 135K miles and still drives like new.
I did add the $40 ECS Tuning transmission dogbone mount insert. This is good for me as I rarely fail to enjoy a brisk (the briskest possible for this car, anyway) acceleration to highway speed: 65, then 70, then 80 for the three phases of my commute. What I am trying to say is that the car has never been grannied. Brakes are very good, too, btw.
Fuel economy is reliably 33 mpg during the summer, 31 mpg in the winter. Pretty much always BP 93 octane.
I prefer Michelin MX4+ Primacy tires (16", OEM size). I have had Continental and Cooper tires. Those were fine, but the Michelins are worth the few extra bucks.
tl; dr: if you have a long highway commute, consider a car built for the autobahn. It's worth the extra cost to not be miserable in your car for ~2 hours every day. Performance and safety features are good, too.