Have it and love it, only issues - S3 hibernation is all buggy, supposedly fixed in the 1.8beta bios, but i don't trust beta's for my bios. Also, there is an issue with enabling EIST and cpuvoltage moving around. Besides that, um, downsides... can't think of much more.
This was by far the easiest build i ever had. Just had three motherboard drivers to install (4 if you are going with a raid setup) and they all worked perfectly. overclocking is a breeze, just a solid board and I don't know why more people don't like MSI on this forum. I am not particular to any given brand, this board replaced an ASUS and i have owned other brands as well. Enjoy!