The first thing I would do is make sure that you have the latest bios, 2.92.
Then I would disable Boot Up Floppy seek, set Gate A20 Option to Fast, disable Video memory shadow, set Fast R-W turn around to Enable, disable legacy audio, (unless you use a midi (mpu-401) connected joystick or other midi device), leave Memory Bank Interleave set to yes, and DRAM Timing by SPD, pnp OS to yes (if you have a pnp OS), enable the Shutdown Temperature function and leave it at the default temp 70C. That has been pretty stable for me anyway.