It should handle it as long as the board supports that much memory. The only time in which you might encounter issues if if you're overclocking. Some say that the extra "strain" on the motherboard because of the 4x memory sticks can make an OC less achievable than with 2 sticks. I've read many anecdotal posts by people who say that they had to nudge their OC down when all four banks were populated. If you're just OCing the CPU and running memory at stock or less, this might not really be a problem.