Hi, This problem has gradually gotten worse over the last week, and it is application dependent. With windows the problem seems erratic. At times I can't click on the taskbar, but can click on icons, or vice versa. Pressing ctrl alt del and closing the task manager fixes the problem temporarily. With Firefox I can't click until I press ctrl alt del, then I can click a link once before the problem repeats. With Chrome I can surf all I want, but can never click the wrench and page icons next to the address bar. I can play games like Team Fortress 2 with no problems. So far I've tried a different mouse, also USB, in different ports. I've tried multiple virus scans. I've tested the RAM, and I've reformatted the harddrive and reinstalled windows. What else can I try? My computer is about 1.5 yrs old with: Q6600 GIGABYTE GA-P35-DS3L 8800GTS Soundblaster X-fi Thank you!