Question Mouse left click, right click unresponsive

[sammytheman]

So I have a strange issue where the mouse stops working. I see the arrow move across the screen and it responds to left clicks or right on my browser for example. The issue is, it does not work anywhere else. Like right now I can click and open different browser tabs but I can't click on anything else like the taskbar. When I scroll my mouse over icons in taskbar, normally it kinda gets highlighted but right now it does not. If I minimize my browser to go to desktop I can't get the mouse to work with eight left click or right click. I only see the arrow. So what I do is ctrl+alt+del and then esc, repeat a few times and eventually the mouse works again. This is a 7 month old custom made PC with genuine windows 10. I have done system restore but that did not help. I have also tried another mouse(wired) and issue persists. Current mouse is wireless by the way. Any advice is greatly appreciated. Thanks in advance fellas

 

[RLGL]

Start by disconnecting all items from the USB system except the wireless mouse, restart. what happens?