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Most Comfortable Mouse

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I use an MX Revolution at work and a G700 at home, both Logitech. For my larger-than-average hands, they fit equally well and feel great after many continuous hours of use.

I had wrist problems then generally used a trackball until I found a mouse that worked for me. I settled on the MX700 / MX1000 / MX Revolution because they didn't give me wrist problems. The odd thing is, I definitely don't have larger-than-average hands.
 
well, you have the options of trackball, vertical mouse, ergonomic, micro, and just about every shape, size and weight combination. if you haven't found one you like, my guess is that you haven't looked.
 
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