I am using a molex to SATA cable adapter for my main disk which has the OS, a Crucial M500. Are there any drawbacks to this, regarding the extra lines a SATA power cable has?
Maybe we should go back and review exactly what wires and voltages are actually used by drives -- whether SSD or HDD. It never occurred to me there might be a difference between SSD and HDD.
Yes, most SSDs other than the Intel 730 series use +5V only.
3.5" HDDs use +12V, primarily for the motor, and +5V for the interface board / electronics.
I'm not sure about 2.5" HDDs, but I suspect that they also only use +5V.
The reason being, is that those USB-to-SATA cables used with cloning software, only support a low-powered +5V device plugged into the SATA end, and I think that they work with SSDs and notebook HDDs. They definitely don't work with 3.5" HDDs though.
However! I frown on using these 8" patch cables in my own builds for anything more than fans or a hot-swap bay (not the boot/system).
Actually I have four SATA power cables from the PSU but I decided to use them for spinners since they are not OS drives (one of them is but I will not be using it much), thinking they might have something to do with the power down options. I have to do some reading of what the extra 3.3V lines do.
Edit. Did a bit of reading at Wikipedia.
Quoting,
"3.3 V is supplied along with the traditional 5 V and 12 V supplies. However, very few drives actually use it, so they may be powered from an old 4-pin Molex connector with an adapter."
"To reduce impedance and increase current capability, each voltage is supplied by three pins in parallel, though one pin in each group is intended for precharging."
"Two ground pins, and one pin for each supplied voltage, support hot-plug precharging."
"Passive adapters are available that convert a 4-pin Molex connector to a SATA power connector, providing the 5 V and 12 V lines available on the Molex connector, but not 3.3 V. There are also 4-pin-Molex-to-SATA power adapters which include electronics to provide 3.3 V power additionally. However, most drives do not require the 3.3 V power line."
Some of the extra pins are for hot swap and some are doubled for better power delivery.
The only thing that concerns me is whether the 3.3V lines are used by the M500 for something.

From further reading I've done it looks like the 3.3V lines were added for the manufacturers but not followed much apart from 1.8" drives and some 2.5 drives.
I asked at Crucial support and the short response of a member was "Looks like the 2.5" models are 5v: http://www.micron.com/~/media/documents/products/product-flyer/brief_m500_ssd.pdf".
The specification part of the flyer.
Edit. I am using 2x1GB for storage, the SSD, a 160GB for second OS and fun, and a 2.5" 500GB that already has some bad sectors in which I am thinking of hosting a few VMs.
Overall the only thing the SATA connector is better is for hot-swap and it also has better power delivery. Well, molex was trustworthy for many years...
Just to confirm that the SSD is working perfectly on the adapter cable, been there for a few hours.
The reason I put it there was because of the case setup. I have the two 1TB in the 5.25 bays, the SSD right below in the floppy bay, and the other two disks below, it's a side bay and has quick remove access. I chose those two there since they are the first ones to replace. The SATA power cables cannot be moved(!) so they have to be used with the 5.25 and side bays.
