The E-50 has some weak spots. The mud flaps in front for example. Extremely weak. Hit it there and watch the hit points drop off the E-50 quick. From what I hear its a bug from back during its beta. They haven't fixed it yet. Btw, the E-75 has the exact same mud flap problem. The E-100 has a lower glacis problem. So aim low between its treads and watch it's HPs drop as well. This is assuming the gun you are using against these tanks has decent power and penetration but those are the weak spots in front.
The E-50 has some weak spots. The mud flaps in front for example. Extremely weak. Hit it there and watch the hit points drop off the E-50 quick. From what I hear its a bug from back during its beta. They haven't fixed it yet. Btw, the E-75 has the exact same mud flap problem. The E-100 has a lower glacis problem. So aim low between its treads and watch it's HPs drop as well. This is assuming the gun you are using against these tanks has decent power and penetration but those are the weak spots in front.
ISU-152 is nice with the BL-10 but the reload time is horrendous and it's still made out of paper. It's a bit like the KV derp of the tier 8s. You wouldn't want to, for example, do a shoot out against a Ferdinand with the BL-10. Yes, you will kill the Ferd in two shots, but you need to land both of them. The Ferd can land the three needed to kill you more accurately. With 0% crits running around, you can't afford to do a non-damaging shot.
ISU-152 has to peek, take a shot, and then get behind something solid for 15 seconds. If it gets caught exposed for a moment it will get shattered.