Hi there. A few things come to mind; I also have gotten the standard "everything is fuxored" error message.
1. Uninstalled and then reinstalled the game? Sometimes, all it takes is a tiny little power fluctuation during a "writing to the HD" period to mess something up big-time." I've had only one game (HalfLife, believe it or not) do this to me. I reinstalled and all the probs went away. I can't explain why.
2. If that's not the problem, I see...your signature. You may be overheating. Just for gags, lower your clock a little and see what happens. A big overclock like that stresses every component in your system. Yes, I know you have good cooling. So do I, but anyones vidcard can overheat.
I hope this helps, or at least gives you a starting point.