This is a very good idea for a thread.
Given my druthers, I think I'd probably not go uATX again. I think there's just not quite the same massive amount of headroom for OCing that there is in the better ATX boards for S775. I am happy with the way things turned out with my P5E-VM HDMI, all in all. Most uATX boards hardly allow for OCing at all, till quite recently. So things have definitely turned around in that area.
I think my biggest difficulty with the P5E-VM is that I have FSB holes everywhere no matter what multipliers I use. I did find a rock solid setting on the 9X multi, thank God, but I could not get the system stable at 4 GHz on either the 10x or 9.5x multis on the G35 chipset. I was fortunate to find a place at 460 FSB (but both the CPU and the NB need significantly increased voltages). Sure enough, if I tweak it just to 461, much less 462-465 or more, I start getting computation errors in OCCT and Prime. 460? Runs like a tank. I may try the 8.5 multi one of these days if I'm feeling experimental, but I think I've found my absolute max on this setup.
I don't see why you would put a uATX board in an ATX case, however. Makes little sense to me, since the best uATX boards are fairly comparable in price to the most established ATX boards. Doing so does allow you to use the better cooling gizmos, however.