It doesn't really matter.
As for the issue of poll rate USB is FIXED at 125hz. (all USB input devices are polled 125 times per second, this cannot be changed)
PS/2 on the otherhand can have its sample rate set anywhere from 20 to 200hz. (In Win2k/XP look in Device Manager at the properties for your mouse to adjust this rate, Win9x requires a third party tool.)
CPU usage on on ethier interface is not measureable.
If anything PS/2 is more compatible. All OSes that support mice will work with PS/2 mice. Such is not the case with USB mice. Personally I always use PS/2, I mean whats the point of wasting a USB port when you already have a designated keyboard and mouse port? PS/2 ports are not likely to disappear from motherboards for quite some time. Abit already tried it with their MAX Legacy free board, by popular demand they released a newer version of the same board, the MAX2, but this time with the PS/2 ports put back on
