- Acute exposure to high levels of 2,4-toluene diisocyanate in humans, via inhalation, results in severe irritation of the skin, eyes, and nose, and causes nausea and vomiting. (2,3)
- Acute animal tests in rats have shown 2,4-toluene diisocyanate to have moderate to extreme acute toxicity from inhalation exposure and low acute toxicity from oral exposure. (1,4)
- Chronic inhalation exposure to 2,4-toluene diisocyanate in workers has caused significant decreases in lung function, an asthma-like reaction characterized by wheezing, dyspnea, and bronchial constriction. (2,3)
- Animal studies have reported irritation of respiratory tissues, bronchopneumonia, and weight loss from chronic exposure to 2,4-toluene diisocyanate. (1,2)
- Animal studies have reported significantly increased incidences of tumors of the pancreas, liver, and mammary glands from exposure to 2,4-toluene diisocyanate via gavage. Animal studies, via inhalation, did not report an increased incidence of tumors.