This is visgf (a soon to be hospital pharmacist):
Enbrel works to suppress the immune systems in major autoimmune diseases such as rheumatoid arthritis, lupus (sometimes), ulcerative colitis, crohns diseases, and sometimes majorly bad psoriasis.
The major fatal events are the possible systemic infections that can occur if your immune system is suppressed. Of particular concern is tuberculosis, although other infections can be severe (like severe pneumonia). There have been a couple cases of people contracting HIV while on this drug, and like all other pathogens in this situation, the HIV virus goes crazy and the infections have gotten vere severe, very fast.
A few people are also prone to developing fluid overload, or edema. This can be dangerous if you already have problems with fluid, like people with congestive heart failure. Some CHF patients have had life threatening events due to their fluid overloaded state.
Drug manufacturers are required to put these warnings in all their direct-to-consumer advertising. It's up to your doctor to decide if you're a good candidate for this drug.
PS: this drug prices in the tens-of-thousands of dollars for a year worth of therapy.