Long scientific explanation of Viagra and other similar drugs

glen

Lifer
Apr 28, 2000
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I hope this thread is ok and does not get locked. I did my best to expalin it as accuratly as possible in clinical language so that it is appropriate, and I think it should be viewed as a scientific post, as it really is not at all sexual, despite being about Viagra.

What exactly is Viagra?
Viagra is specifically a cyclic guanosine monophosphate phosphodiesterase type 5 specific inhibitor

Maybe I can give a good answer because I have worked in a pharmacy that sort of specialized in this stuff. This is from memory, so maybe some details are wrong, but the basics are there, and I think it will answer most folks quests. If it doesn't reply back, I am will answer them.

Viagra increases the blood flow. You have 3 spongy tissues in your penis, the Corpus Cavernousum ? 2 of them the top of your penis, and the one on the bottom is the Corpus Spongiousum.
:Q assume that is a cross section of the penis, the eyes are the Corpus Cavernousum, and the mouth is the Corpus Spongiousum. In female the clitoris?s underlying erectile tissue is the is the Corpus Cavernousum. To get these tissues erect, they need to fill with arterial blood, and the drainage to the veins needs to be slowed. When you have an erection, the upward angle sort of pinches off the veins draining the blood. These veins are in the top of you penis near the surface, so when it is up right, it is sort of like folding a water hose...no water comes out the hose swells and becomes harder, but if you bend your penis downward, or unfold the hose, you see the swelling subside. Make sense?



Anyway, cyclic guanosine monophosphate phosphodiesterase type 5 is an enzyme that lets you loose your erection. So, basically all Viagra does is inhibit that enzyme. So, it does not give you an erection, but if you get one, it helps you keep it up until you ejaculate, at which point some other enzyme over whelms the inhibitory action of the Viagra. Also, like if you are starting to get one, but you are only semi ridged, the Viagra would put you over the top in that situation. If you have too much Viagra in your system, you may not totally lose your erection after ejacualtion. That is not as great as it seems. What we want is somethign that shortens the refractory period, the time it takes to get another errection after you ejacualte. For teenagers, this is almost instantaniousl, while for older folks, it might be a few hours. Viagra does not really help with this, nor is it intended to

What about some of the other drugs? Well, you can inject about a tenth of a CC of prostaglandin into a penis, and anyone but a dead man will get an erection. There are a few problems with this.
1.Who wants to stick a needle there?
2.The erection does not go away even after ejaculation. You simply inject, and you got an erection, no matter what. It can last for 1 hour, or more. If it goes over 4, you lose oxygen to the tissue, and that is bad and you might have to cut out the dead tissue. Obviously this is a bad thing. So, guys if for what eve reason you get one for over 3 hours, get to the emergency room ? seriously!
3. The last problem is something that I think all guys can understand, but I am not sure that females can or do experience this. The sort of erection you get from prostaglandin is painful. Now, I don?t know why, but we have all experienced this, some erections are fine, and sometime they frigin hurt, and that is basically the kind you get from the shots. Now, if you can't get one any other way, you are probably happy to deal with this side effect.

Funny anecdote:
The guy that figured this out is a Urologist named Goldstein, I think. He delivered a long paper at a Urology conference about the theory and how erections and prostaglandin effects them. It was a 45min or 1 hour long talk. He was in front of hundreds of doctors, up on a stage, delivering a scientific talk- nothing erotic at all about the situation. He was standing behind a podium, and wearing a trench coat. After the talk, he announced that he had injected himself just prior to the talk. He steps out from behind the podium, and takes off the trench coat and he is not wearing pants. Then he walked around the audience. He is not perverted, it is just the kind of thing that one proves his theory is correct, and two funny as hell, and three they are all doctors and urologists and their profession in life basically involves looking at penises.
 

Squisher

Lifer
Aug 17, 2000
21,204
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Well I learned two things:

How Viagra causes erections and that Urologists can take their work too far.

 

AsianriceX

Golden Member
Dec 30, 2001
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Your diagram of the cross-section of a penis is astounding. I feel like a better man after seeing that.

:Q:D
 

glen

Lifer
Apr 28, 2000
15,995
1
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Originally posted by: AsianriceX
Your diagram of the cross-section of a penis is astounding. I feel like a better man after seeing that.

:Q:D

Well, that is pretty much how it looks when you cut one in half. I have done it too a few, but don't worry the person was dead, and I was in medical school. All these new sexual function drugs are in the media these days, yet no one explains to lay people exactly how they work. It is slightly explained as if the rest were secret knowledge or black magic the general public would not under stand. I am really opposed to this arrogance. I think people should know this stuff.
 

Slickone

Diamond Member
Dec 31, 1999
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Good post Glen. Remember, there are a lot of younger people here in OT, but I'm sure many other people here find this info useful to know (maybe if not now, for one day) but aren't going to speak up. Also from what I hear a lot of people that don't really need it are using these drugs for experimentation, if only once.
But you went into talking about the injections, and when to go to the hospital, but maybe you should clarify that (I think?) that implies to any of these drugs, incl. Viagra, not just the injections. Correct?

Cliff notes?
"If it goes over 4, you lose oxygen to the tissue, and that is bad and you might have to cut out the dead tissue."
 

glen

Lifer
Apr 28, 2000
15,995
1
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Originally posted by: Slickone
Good post Glen. Remember, there are a lot of younger people here in OT, but I'm sure many other people here find this info useful to know (maybe if not now, for one day) but aren't going to speak up. Also from what I hear a lot of people that don't really need it are using these drugs for experimentation, if only once.
But you went into talking about the injections, and when to go to the hospital, but maybe you should clarify that (I think?) that implies to any of these drugs, incl. Viagra, not just the injections. Correct?

Cliff notes?
"If it goes over 4, you lose oxygen to the tissue, and that is bad and you might have to cut out the dead tissue."

If you are a normal male, Viagra, Cialis, and Levitra, won't do anything to you.

If someone, like maybe 60 years old takes them, they will not get an erection until stimulated, then after orgasm it will go back down.

Some people who have nerve damage need a little more help than these drugs provide. So, if you are all but dead, an injection of Prostaglandin, and a few other things, will give you an erection for 1 or more hours. Your erection will not go away even if you ejaculate. You administer the shots to yourself at home when you are ready. If you don?t get the dosage right, you are in danger of having an erection for hours and hours, and tissue damage from lack of oxygen will set in and you might have to get it amputated. 4 hours is considered the time for damage to set in, so I would suggest if you are at 3 hours, get the heck to the emergency room, or like they said in The Big Lebowski, "Vhe believe in nussing Lebowski!, Nussing; und tomorrow vhe come back and vhe cut off your johnson!"
 

Slickone

Diamond Member
Dec 31, 1999
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So are you saying that can't happen with any of the pills, and only with the injections? I know I've heard it can happen with pills, but whether I heard right, I don't know. However this says:
LEVITRA may uncommonly cause:
* An erection that won't go away (priapism). If you get an erection that lasts more than 4 hours, get medical help right away. Priapism must be treated as soon as possible or lasting damage can happen to your penis including the inability to have erections.
 

glen

Lifer
Apr 28, 2000
15,995
1
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Originally posted by: Slickone
So are you saying that can't happen with any of the pills, and only with the injections? I know I've heard it can happen with pills, but whether I heard right, I don't know. However this says:
LEVITRA may uncommonly cause:
* An erection that won't go away (priapism). If you get an erection that lasts more than 4 hours, get medical help right away. Priapism must be treated as soon as possible or lasting damage can happen to your penis including the inability to have erections.

Anything can but I suspect they put that in there as a wink wink makes you last longer thna a sincere warning. Any of these drugs can increase the likelyhood of priapism, but not like the injections can.