Most people think it doesn't have any real penetration power so they keep it loaded with birdshot which will easily shoot through both one and two drywalls and kill people.
What you'd want is something that doesn't penetrate a body but leaves all the energy inside... like some sort of a ... i dunno... say a 7.62x51 round that is high powered enough to reach a target far away and stop once it hits a target without so much as leaving an exit wound...
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I have zero faith in birdshot stopping someone if I actually hit them with it. No reasonable way it can penetrate multiple walls (even just drywall) and still kill someone. I am sure its "possible" just like its "possible" that you can take your rifle outside shoot it up in the air and have the angle perfect enough for the bullet to come back down in the same spot you shot it from. Neither are very damned likely though.
Birdshot is a real good way to piss off a bad guy while leaving him with the ability to return fire. Buckshot is what you want loaded in a shotgun meant for home defense. Slugs are effective at teaching bad guys the difference between cover and concealment but I wouldn't have them loaded in my home defense gun because of collateral damage issues.