if you don't want to take a loss then put a reserve on it and start the auction low...
if you are willing to take a gamble then sell it no reserve
In response to Richie, while you cannot can your auction in the last 12 hours one can generally tell how well something will do from the number of hits it gets, the activity, and the watchers...while there are exceptions to the rule generally if an Item I am selling gets alot of looks and watchers and bids up quickly even if it doesn't hit the target I would like I generally assume it will sell well...which it always does.
And as for background, I was just offered the opportunity to be a powerseller this past week but declined as I don't intend on selling much more for a while....most of my sales are used/discarded laptops and computer parts.