Two of four run 24/7. One is a server.
The other is my information and media center.
If I watch a movie and want to check some info on actor's bio, or get some facts checked while following History channel documentary, or how to get to some address in town, or just watch same music videos (ones I want to see - not the ones on MTV at the time), or simply set some music background for whatever I do at the moment, I just don't like to wait for boot-up, even if it takes 90 seconds.
I run Win 2k server and win 2k and never have problems with bleeding memory.
Sometimes I just check list of running processess for ones that didn't close when they should.
I don't overclock, my SCSI drives are packed in Ultimate Coolers, and I don't care if these systems die after 4 or 14 years as long as they work dependably 3-4 years (maybe 5-6 years for SCSI drives).
Soon I'll install additional system in the kitchen, also planned to run 24/7 for the same reasons as above