<< Do you have to adjust your card before each game??? >>
No you don't, you can add settings to a profile for each game but it's really not needed.
I just run everything with the default settings, works fine for me, except for one thing, I enable "force texture compression"
Make sure you download the latest drivers and away you go, it would also be a good idea to get the latest stuff for your motherboard like the latest bios etc. That's pretty much standard practice if you got any new hardware.
Nemesis