Well so far i haven't seen a decent response to this post so I'll give you what knowledge I have regarding speaker placement.
First of all subwoofers produce frequencies below 120 hz (usually lower but in a multimedia application probably 120hz) and these frequencies are non-directional. I saw one post about a guy saying that the bass needed to 'mesh' with the highs by being close, but honestly, unless you're placing your sub more than 5-6 feet away from them, this should not be a problem. The only time this becomes a problem is when you have a sub no where near your other speakers and no where near you, the timing starts to get off and a DSP processor becomes necessary, but again, for multimedia applications this really is unnecessary.
Secondly, subwoofer placement can be basically anywhere that sounds good in your room. If you like a really LOUD BOOMY subwoofer, try to place it in a corner with about 2 inches minimum on either side. Having 2 walls for your subwoofer's frequencies to resonate off of helps to generate the most amount of bass. I personally don't like this sound, but for a system that lacks bass, this is a good way to create it.
Your other option would be to place it near one wall. Having this one wall gives your subwoofer at least something to resonate from (since you mentioned this is a side firing subwoofer this is actually almost necessary to get decent bass response) and will give you a nice tight warm sound. Don't place your sub too close to the computer, you could cause your hard drive needle to bounce, and yes this is possible for you skeptics. Give at least 2 feet of room between your sub and your computer to be safe.
The ultimate listening test would be to pick a song that you REALLY like and REALLY know well. Place the sub in a few different places, listening to the whole song in its entirety. Listen for things you normally don't hear in the song. If you notice particular nuances in the music when the sub is in a certain position, this is the place for you.
I hope this helps somewhat in positioning your subwoofer.
divinemartyr