like where/what? elaborate.
16th century China, or maybe somewhere around 12th century Japan......either of which would provide a backdrop for some incredible artistic direction.
Late 1800's western U.S. - - tons of possibility there, if they could manage to stay away from the cheesy Hollywood junk.
STALKER was an incredibly creative idea....although more an FPS than RPG, you could easily take the concept the other way.
How about the African savanna? Maybe southern Mexico during the time period of Mayan control?
I know there are a few games out there in some of the periods above, but there certainly doesn't seem to be much interest in really branching out from the norm.