Same thing happened on my Gigabyte Z170 motherboard. I lost the ability to set a fan profile, and their apps just crashed over and over.
After trying to get it to work for over 9 months, I just gave up. Then one day they added the ability to do fan profiles in the UEFI with a major BIOS update, and I've never installed motherboard utilities ever again.
Your Asus board should allow you to configure your fans in the UEFI, I know I can on my son's Asus Z97 motherboard.