It's 70% memory related, 20% powersupply related... or... 10% a bad motherboard instalation.
Perhaps a metalic part of the PCB is touching another metalic part on your case, making a short suddenly.
Perhaps memory options are off-set, and you should lower your timings. Try fail-safe 3-3-3-8 settings, if running in DDR400 mode. Also, check, if using two memory slots, that they are exactly the ones you need to fill in order to run at Dual Channel DDR mode.