Of course! Use your imagination!
What youll need: either active speakers (i.e with built in amp) or a standalone amp with speakers coonected to it. Heck, you can even connect your pc to a stereo, as long as it has l/r inputs. My PC has audio branching (ie LOTS of cables). It has a signal splitter (cuz i connected it to 2 sorround sound systems), one 5.1 connection goes to my room aiwa surround sound system (never bought gay computer speakers in my life! If iu have a stereo, why not connect to it, for better sound, and to save??!), and the other 5.1 goes to the other room with big-ass surround sound system (for music listening).
Tell me bout your config, what speakers/equipment you got! ill help with cable selection and like!