Wired will normally always be better, though I've tried some wireless headphones I setup for someone and I found they sounded pretty good, but it was in a hospital environment and they were randomly picking up random interference, but I only noticed that while there was no sound being transmitted to them. Need to tell the old man next door to turn his heart monitor down! :biggrin:
If you're picking up interference, then it's probably the wrong technology.
I have my Sennheiser RS160 on my head right now, with nothing playing, in a silent private office. I hear nothing. With my RS180 in my home office, same silence. In my home theatre system though, I do get a slight background hum, which I'm wondering could be a ground loop or something for the transmitter. I'll have to try to eliminate that.
In contrast, I couldn't use the RS120 at all since I had to sit in a specific spot with my head held in a very specific way, or else I'd get interference. FM wireless sucks for headphones IMO. I returned it the next day.
The RS180 is a very good set of headphones, even by wired standards. People say the Sennheiser RS180 wireless headphones are on par with the Sennheiser HD558 wired headphones. I do like the sound out of my HD598 wired headphones a bit better though.