Dust isn't dangerous for your hardware as long as you don't let it bog up your fans and heatsinks, and you seem to be very careful about it....cleaning at least once a week sounds a little fanatic to me

but the amount of dust varies greatly from place to place.
Having your case open *could* lead to increased EMI (electromagnetic impulses) emmision which *could* influence on your other hardware (especially if you have some sensitive sensors or such around). But it's nothing to be frantic about if you aren't having any problems in this matter.
The greatest danger IMHO is the more physical damage that could happen to your computer, if something drops down into it (pencils, fluids and other), or if someone (be that kids, pets and yourself

) wants to see just how fast that Delta Extreme Scream 7k RPM rotates. At least having something at the top of the computer (a plate or something else) is a good idea in my book, as this prevents the more common array of dropped items.