Its all I use. Safari is so slow to load, and slow to load extra tabs, I've found that if you turn off the 'Top Sites' preview and have new tabs load 'blank' that speeds it up a little. Plus Safari isnt running new tabs as new processes, so a crashed tab takes down the whole browser, but not in Chrome. Chrome runs each tab as an isolated process. Another benefit of that is when you close a tab you tend to get more memory back. Safari hogs memory, even after closing multiple tabs (my buddy switched for this very reason). Also Chrome is now hosting and updating Flash by itself. No more manual installs for Flash updates.
Chrome just starts and runs so much smoother and faster. I used to be a huge fan of Firefox, but 3.0, 3.5 and 3.6 are just DOG slow on OS/X (even on Windows compared to Chrome). I'm interested to see if Firefox 4 is faster... Tried a beta of it last month and was unimpressed thus far.