I presume that this benchmark is the SisSoft Sandra memory benchmark? The numbers look about right anyway.
This benchmark is intended to pound the memory subsystem in order to try and maximize the peak throughput of the memory subsystem. It attempts to eliminate the effect of the CPU's cache by moving blocks of uncached data around and measured how fast it can move this data. Seeing a somewhat large difference doesn't mean that your system will perform substantially faster in the real world. In the real world very few applications are moving large blocks of uncached data around.
A more interesting benchmark would be BapCo, or ZD's Content Creation, or WinStone. Something that actually mimics real-world applications. I'm fairly confident that the numbers will drop to somewhere below 5% were you to do this.
Then there's the question as to whether or not even a 10% improvement in performance is "noticeable" in real world applications. If spell check takes 9 seconds rather than 10 sec., is this a noticeable improvement? If you get 66 frames per second in Quake3 rather than 60 frames per second, is this really noticeable?
There are very few applications that will see a substantial improvement in performance by enabling interleaving (SETI@Home is one). In fact, I have heard of a few cases in the real world where interleaving actually results in a performance hit rather than an improvement. But, like I said, there's no reason not to enable interleaving if you can. Usually it's a small, free improvement to memory subsystem performance.