If you are taking bluray source material and transcoding it to the maximum quality per bit for media server and/or archiving purposes, I would stick with x264.
If you are doing anything else, encoding down to 720 or lower for mobile devices or web production, the slightly slightly softer edges from QuickSync will not be noticeable.
Once I used a batch file renamer to see if I could tell the difference between a QuickSync output screenshot vs x264. I could never actually make the distinction correctly, but once I had the pics named properly, my mind "decided" that the QuickSync images were 0.1% noisier. That's just my bias for x264 I guess, but QS is without a doubt a close second to x264, and it's so stupefyingly fast that the negligible loss of accuracy should be forgiven.
Really subjective topic though... gotta try QS and x264 on your own material and take the pepsi challenge. The insane speed is such that you would be remiss if you did not attempt to advocate QS for at least some of the encoding you do.