NFS4
No Lifer
IMHO, people see Opteron's 64-bit backwards compatibility and forget that this also means that the AMD64 ISA is carrying all the baggage of the hideous monster that x86 has become. IA64 is a much cleaner architecture that should allow for better scaling as well as better cost/performance in the future.
As hideous as it may be, people are NOT ready to make the complete switch so a hybrid solution sounds like the best answer...for now.