Depends. If you want to use a Kaby Lake CPU, then the 200-series boards should support them out of the box, whereas most 100-series boards require a BIOS flash using a Skylake CPU first.
Also, most of the higher-end (higher than H110, not sure if an H210 exists) 200-series boards will have two M.2 sockets, and support for Optane Memory cache SSDs. 100-series boards don't support Optane.
OTOH, I expect 100-series boards to sell at a discount, at this point, except for the H110 boards.