Instances of Directors going completely away from their normal types of movies.

[chuckywang]

Tom Shadyac - Director of laugh-out-loud gag comedies such as Ace Ventura, Liar Liar and The Nutty Professor directing a very heavy drama called Dragonfly.

Jerry Zucker - Director of parody comedies such as Airplane! and Top Secret! (as well as producer of the Naked Gun movies directing Ghost.

Wes Craven - Director of scary movies such as the Scream movies and The Nightmare on Elm Street directing Music of the Heart.

 

[MisterJackson]

They say "Inside Man" is something Spike Lee is not known for doing?

 

[anxi80]

if darren arofonsky (requiem for a dream, pi) does commit to 'lone wolf and cub', then that will be a change for him.

some people have even said that 'the island' was a bit of a change of style usually accustomed to michael bay.

 

[chuckywang]

Got another one:

Alfonso Cuarón - Director of such sex romps as Great Expectations and Y Tu Mama Tambien directing Harry Potter and the Prisoner of Azkaban.

 

[kogase]

Terry Gilliam - Fisher King
Martin Scorcese - Gangs of New York (sucked by the way, pretty stupid)

 

[IronWing]

Igmar Bergman - The Muppet Movie

 

[imported_LoKe]

Gus Van Sant -> Responsible for Psycho, Good Will Hunting, Finding Forrester, Psycho and, for some damn reason, Gerry.

 

[JEDI]

Gregory Dark, porn director, directed a Britney Spears video

(yes, she knew his past credits)